Research Opportunities at ucla

Understanding Enzymatic Transformation of small molecules using mass spectrometry and machine learning

UCLA PI Name: Hosein Mohimani
E-Mail: hmohimani@g.ucla.edu
Division/Department: School of Medicine, Computational Medicine Department
Expected Weekly Time Commitment: 10-20 hours

Project description: Enzymes chemically transform small molecules. Understanding these transformations can help us figure out why some small molecule drugs are active in some patients, but inactive in others. Additionally, these reactions explain why people digest dietary molecules from food differently. Finally, knowledge of how enzymes change molecules can help us to optimize drug leads for the highest activity and least toxicity.

Recent methodological advances in machine learning have enabled predicting which enzymes react on small molecules and identifying the product of these reactions. However, currently, these methods have poor performance outside their training data. The major obstacle is that training data on the reaction of enzymes on small molecules is limited and non-homogenous. The goal of this project is to collect data on the reaction of hundreds of enzymes on thousands of small molecules using high-throughput mass spectrometry. The next step will be development of machine learning models based in this dataset to predict how enzymes modify small molecules.

Qualifications or skill required: 

Senior in Chemistry or Biochemistry

Application instructions:

To apply, please send a resume to hmohimani@g.ucla.edu.

Research Opportunities at ucla

Study of cancer biomarkers using ELISA and molecular techniques

UCLA PI Name: Liying Zhang
E-Mail: LiyingZhang@mednet.ucla.edu
Division/Department: Pathology and Laboratory Medicine
Lab website: https://www.uclahealth.org/departments/pathology/meet-our-faculty/liying-zhang-md-phd
Expected Weekly Time Commitment: 20

Job Description:

Are you looking to make a tangible impact in the fight against cancer? The Department of Pathology and Lab Medicine is seeking a motivated Volunteer Research Assistant to join the visionary lab of Dr. Liying Zhang. This isn’t just a volunteer role—it’s a front-row seat to the future of biomedical science.

The Mission
You will play a vital role in supporting cutting-edge research focused on the identification and detection of biomarkers. Our work spans tumor specimens, blood, and other bodily fluids, aiming to revolutionize how we handle:

• Early Diagnosis: Finding cancer sooner.
• Prognosis: Predicting patient outcomes with precision.
• Treatment: Personalizing therapies for better results.

Why Join Us?
• Hands-on Experience: Move beyond the textbook and gain real-world laboratory skills.
• Meaningful Contribution: Work on “liquid biopsy” and tissue research that directly impacts patient care.
• Mentorship: Learn under the guidance of Dr. Liying Zhang in a collaborative, high-impact environment.

Key responsibilities include:
• Research & Collaboration: Participate in weekly lab meetings and conduct targeted literature reviews for reagents (antibodies) and experimental protocols.
• Wet Lab Operations: Assist with specimen processing and management; perform molecular techniques including ELISA, PCR, and nucleic acid extraction from biospecimens.
• Data & Analysis: Analyze experimental results and maintain accurate digital/physical records.
• Lab Management: Oversee daily operations, including inventory/ordering, equipment maintenance, and biohazardous waste disposal in compliance with safety standards.
• Mentorship: Lead the training and onboarding of new undergraduate researchers.

Application Instructions:

To apply, please combine your Research Statement, CV, and academic transcript into a single PDF file and email it directly to Dr. Liying Zhang (LiyingZhang@mednet.ucla.edu).

Research Opportunities at ucla

Particle Laden Flow

PI Name: Andrea Bertozzi
E-Mail: bertozzi@ucla.edu
Division/Department: Math/Mech E
Expected Weekly Time Commitment: 40 hours

Job Description:

Looking for undergraduate researcher who has no lab experience outside of the classroom, and is eligible for nomination for the SRS program at UCLA.
Research will involve conducting table top experiments on particle laden flow including camera imaging, particle image velocimetry (lasers), and data processing from the experiment. Some background in fluid dynamics is a plus. You will be working alongside three other REU students who are part of the math department computational and applied mathematics REU, with mostly overlapping time with the SRS program. You need to be eligible for all dates in the SRS program from June 22 to Aug 28, 2026. The lab is in the Math Department right next to Boelter Hall.

Application Instructions:

Send your transcript or DPR to bertozzi@ucla.edu along with names of two faculty with whom you have finished taking a class who can provide a letter or feedback about your performance in the class.

Research Opportunities at ucla

Neurology Undergraduate Research Assistant/Volunteer

UCLA PI Name: Keith Vossel
E-Mail: kcassiano@mednet.ucla.edu
Division/Department: Neurology
Lab website (if applicable): https://vossellab.dgsom.ucla.edu/
Expected Weekly Time Commitment: 10-15 hrs

Job Description:

We are looking for Undergraduate students looking for experience in a Clinical Lab setting. Job duties include but are not limited to:
– Conduct screening calls for potential research participants regarding family medical history and continued interest in lab’s recruiting studies
– Acquired formal training in participant screening procedures, study workflow management including medical data collection and compliance
– Report to clinical staff on progress

Preferable:
– Bilingual (Spanish)
– Music Production/Software knowledge or Music Industry Minor
– Clinical experience (hospital volunteering, senior centers, etc.)
– Good interpersonal skills and effective communicator

Application Instructions:

Please email Coordinator Kate Cassiano at kcassiano@mednet.ucla.edu with your resume, CV, and a short message explaining your interest.

Research Opportunities at ucla

High-content drug screening and cell phenotyping

UCLA PI Name: Neil Lin
E-Mail: neillin@g.ucla.edu
Division/Department: Bioengineering
Lab website: https://www.linlab.seas.ucla.edu/
Expected Weekly Time Commitment: 5 to 10 hours per week

Job Description:

The Lin Lab is seeking undergraduate researchers starting between now and June 2026. This opportunity focuses on mechanobiology-driven digital biology for tissue engineering, offering students comprehensive training in advanced live imaging, biosensor engineering, and AI modeling to explore cell metabolism and therapeutic targets. Candidates can pursue one of two distinct projects: conducting high-content pharmacological screening to build LLM-based “digital twins” for virtual drug discovery, or designing novel fluorescent biosensors to dissect biomechanical and biochemical regulation of organelle remodeling.

Application Instructions:

Please email your CV/resume to PI Neil Lin to arrange a meeting.

Research Opportunities at ucla

Research Intern (Off-campus: Cedars-Sinai)

Division/Department Overview:

The Department of Pathology and Laboratory Medicine (DPLM) at Cedars-Sinai Medical Center (CSMC) is one of the nation’s premier academic pathology departments.  The DPLM provides exceptional diagnostic support to help physicians guide patient therapy at CSMC and its affiliated hospitals.  CSMC is ranked by US News and World Reports as one of the top-10 hospitals in the nation.

In addition to world-class patient care services, the DPLM has 10 basic and translational research laboratories which study a wide range of biomedical topics including cancer biology, microbiology, renal disease and physiology, immune function, neurodevelopment and neurodegeneration.  Dr. Tourtellotte’s lab is funded by the NIH to study molecular mechanisms regulating neurodevelopment and peripheral and central neurogenerative disease such as Alzheimer’s disease.  He has mentored many PhD and MD/PhD students who have performed their dissertation research in his lab, and he is actively involved in mentoring undergraduate students, medical students and clinical residents and fellows.

Job Description:

The research intern will work closely under the supervision of senior scientists and the PI in the lab to learn molecular and biochemical techniques and participate in ongoing research projects.  A wide range of molecular, biochemical, morphological and tissue culture techniques are used in the lab to elucidate basic mechanisms of development and neurogenerative diseases.  In addition, the lab generates transgenic and gene targeted mice to model disease mechanisms that require behavioral, microsurgical, histological and physiologic techniques to analyze disease-related phenotypes and mechanisms.

Role Activities & Timeline:

Provide a detailed description of the activities that will be completed during this appointment. For interns, this should include specific information regarding mentorship and curriculum, including an intended timeline for the activities.
By the end of each quarter (3 months)
•    The intern will broaden their research skills through training under the mentorship and supervision of the lab’s faculty mentor.
•    The intern will learn how to perform molecular cloning using RT-PCR, PCR, restriction enzyme digestion, ligation, and cell transformation.
•    The intern will learn proper recordkeeping by documenting data in lab notebooks and presenting findings to the mentor and in departmental presentations.
•    The intern will learn how to conduct a literature review related to the project they are training on.
•    The intern will learn how to design experiments based on specific research questions.
•    The intern will practice implementing experimental designs and troubleshooting issues that may arise.

Requirements:
•    Must be 18 years of age or older.
•    Must have a HS Diploma or GED.
•    Must reside in the greater Los Angeles area or surrounding cities while conducting all activities related to the intern or visitor appointment.
•    INTERNS: Those participating for academic credit must receive academic credit for the duration of the internship.
•    VISITORS: Must be receiving funding from an eligible sponsoring institution (employer, educator, funder, etc.).

Preferred Education & Experience:
Undergraduates enrolled in a life sciences degree program with strong interest in biomedical research.  Interest in pursuing advanced graduate medical (MD), life science graduate (PhD) or physician-scientist (MD/PhD) is the typical aspiration of students who are particularly successful in this internship program.  A passion for advancing scientific discovery and medial knowledge is highly desirable.

Application Instructions:

Apply using the following link: https://careers.cshs.org/job/los-angeles/research-intern/252/91186630416

Research Opportunities at ucla

Asian Linguistics Website

UCLA PI Name: Shoichi Iwasaki
E-Mail: iwasaki@humnet.ucla.edu
Division/Department: Asian Languages and Cultures
Expected Weekly Time Commitment: Fiver hours per week; Winter and Spring quarters 2026

Job Description: A paid student assistant position (based on the current university rate)

To develop a webpage for Asian linguistics in coordination with a faculty in the Asian Languages and Cultures Department and a Humtech programmer

Requirements:
Web development (HTML and CSS)
Experience with a CMS such as WordPress.

Application Instructions:

Send your CV to Prof Shoichi Iwasaki (iwasaki@humnet.ucla.edu)

Research Opportunities at ucla

Signal Denoising with Diffusion-Based Machine Learning Models (Dry-Lab)

UCLA PI Name: Louis Bouchard
Division/Department: Chemistry and Biochemistry
Lab website: https://sites.google.com/view/bouchardlabucla/
Expected Weekly Time Commitment: 10 hours per week

Job Description:

Our lab, led by Professor Louis Bouchard, focuses on developing computational methods at the intersection of chemistry, biochemistry, physics, and data science. We are looking to onboard students to join the dry lab side of our project.

The dry-lab position is centered on numerical modeling, data analysis, and algorithm development. One of our current projects investigates signal denoising, the process of recovering clean signals from noisy measurements, which is a major topic in spectroscopy, medical imaging, and other data-intensive experimental sciences. The project explores a generalized denoising framework based on stochastic differential equations (SDEs), drawing inspiration from modern diffusion models and score-based generative modeling.

As a research assistant, you will work with modern Python-based tools for signal processing and machine learning, benchmark SDE-based denoising methods against established baselines, and contribute to the theoretical and computational validation of a framework with potential applications across multiple scientific domains. This position is particularly well-suited for students interested in applied mathematics, machine learning, computational chemistry or physics, and data-driven modeling. Prior experience with Python programming is required, and familiarity with scientific computing or statistics is a plus.

Application Instructions:
Please fill out the following Google form, and attach your resume/CV. For inquiries, email jonathankim1626@ucla.edu.

Recruitment Form:
https://forms.gle/8PiVqzdeLLoYqJic7

Research Opportunities at ucla

Pathological analysis for prostate cancer research program

UCLA PI Name: Jianyu Rao
E-Mail: JRao@mednet.ucla.edu
Division/Department: Pathology and Lab Med
Expected Weekly Time Commitment: 10 to 15 hours

Job Description: Engaging in prostate cancer research, help lab staffs to process tissue samples and perform basic lab activities including special stains such as immunohistochemistry, prepare and organize slides, data analysis, etc.

Application Instructions: – Submit CV to Dr. Huang, Rong Rong (rhuang@mednet.ucla.edu), lab manager of Prostate SPORE lab
– Qualified individuals will be invited to in-person interview

Research Opportunities at ucla

Chemoproteomic reagent development

UCLA PI Name: Keriann Backus
E-Mail: kbackus@mednet.ucla.edu
Division/Department: Biological Chemistry
Lab website (if applicable): backuslab.com
Expected Weekly Time Commitment: 15h/week

Job Description: Looking for an undergraduate researcher with a strong desire to work at the interface of chemistry and biology who is interested in using organic chemistry to develop chemical tools to probe fundamental biology. This position is a unique opportunity for an undergraduate student interested in contributing to research at the interface of technology for drug development.

Desired Majors
• Chemistry
• Biochemistry
• Chemical Engineering

Required Qualifications
• Completed general chemistry coursework (20A/B/L/30AL)
• Background or interest in chemical synthesis and chemical biology

Preferred Qualifications
• Experience with organic chemistry
• Completed or currently enrolled in organic chemistry coursework (30 A/B/C/BL/CL), prior research experience in chemistry
• First- or second-year UCLA undergraduate students are strongly encouraged to apply.
• Expected commitment: part-time during the academic year with potential for expanded summer research. MUST have at least 2-3 blocks of 5 hour time in schedule to devote to research

Application Instructions: Interested students should send:
• A short statement of interest (max 1 page) describing relevant coursework, programming experience, and research interests
• A resume/CV (including GPA and coursework)
• Optional Supplemental Materials (Course presentations or Slide Deck Explaining Previous Experience)