Mechanisms to rejuvenate and protect livers from graft rejection following organ transplantation

**THIS POSITION IS NOW CLOSED FOR APPLICATIONS AND WILL REOPEN IN SPRING 2026**

UCLA PI Name: Jerzy Kupiec-Weglinski
Division/Department: Liver and Pancreas Transplantation/Department of Surgery
Expected Weekly Time Commitment: 8-10 h

Our lab focuses on molecular approaches to study the immunology of liver graft rejection, with a particular emphasis on ischemia-reperfusion injury (IRI). We study how immune responses, gene regulation, and cellular interactions contribute to liver damage and explore novel therapeutic strategies to prevent graft rejection. We seek motivated individuals eager to learn cutting-edge techniques, contribute to our collaborative efforts, and gain valuable experience in this innovative field. We are specifically interested in understanding how the interface of the hepatocytes interact with infiltrating immune cells during sterile inflammation. We are developing small molecules to modulate the antigen expression of certain surface receptors to negatively regulate the immune response. The methodologies we use involve mouse animal models, molecular and cellular based assays, and flow cytometry. The student should be available for at least 8-10 h per week. The research opportunity may be used in conjunction with independent research study or appropriate class for a class grade.

Please register at this site: https://forms.gle/TUH1w29Zetvf5yRj6